Π€Ρ€Π°Π·Ρ‹ Π² ΠΏΠΎΡ…ΠΎΠΆΠ΅ΠΌ контСкстС
ΠŸΡ€ΠΈΠΌΠ΅Ρ€Ρ‹ ΠΏΠ΅Ρ€Π΅Π²ΠΎΠ΄Π°
One hundred rad is sufficient to mutate chromosomes in a way that differs from the mutation caused by burns or chemical materials.
Одной сотни Ρ€Π°Π΄ достаточно для Ρ‚ΠΎΠ³ΠΎ, Ρ‡Ρ‚ΠΎΠ±Ρ‹ Π²Ρ‹Π·Π²Π°Ρ‚ΡŒ ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ хромосом, ΠΎΡ‚Π»ΠΈΡ‡Π°ΡŽΡ‰ΡƒΡŽΡΡ ΠΎΡ‚ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, которая происходит Π² Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ ΠΎΠΆΠΎΠ³ΠΎΠ² ΠΈΠ»ΠΈ воздСйствия химичСских ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ².
In the present report, the doubling dose has been estimated using spontaneous mutation rates of human genes and radiation-induced mutation rates of mouse genes, because there are no data on radiation-induced mutations in humans.
Π’ настоящСм Π΄ΠΎΠΊΠ»Π°Π΄Π΅ для ΠΎΡ†Π΅Π½ΠΊΠΈ ΡƒΠ΄Π²Π°ΠΈΠ²Π°ΡŽΡ‰Π΅ΠΉ Π΄ΠΎΠ·Ρ‹ использовались ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ ΡΠ°ΠΌΠΎΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ»ΡŒΠ½ΠΎΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ чСловСчСских Π³Π΅Π½ΠΎΠ² ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Π²Ρ‹Π·Π²Π°Π½Π½ΠΎΠΉ ΠΈΠ·Π»ΡƒΡ‡Π΅Π½ΠΈΠ΅ΠΌ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ ΠΌΡ‹ΡˆΠΈΠ½Ρ‹Ρ… Π³Π΅Π½ΠΎΠ², ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ Π½ΠΈΠΊΠ°ΠΊΠΈΡ… Π΄Π°Π½Π½Ρ‹Ρ… ΠΎ Π²Ρ‹Π·Ρ‹Π²Π°Π΅ΠΌΡ‹Ρ… ΠΈΠ·Π»ΡƒΡ‡Π΅Π½ΠΈΠ΅ΠΌ Π³Π΅Π½Π½Ρ‹Ρ… мутациях Ρƒ людСй Π½Π΅ имССтся.
Off-type (including mutation, abberants)
ΠžΡ‚ΠΊΠ»ΠΎΠ½Π΅Π½ΠΈΠ΅ ΠΎΡ‚ сорта (Π² Ρ‚.Ρ‡. мутация, Π°Π±Π±Π΅Ρ€Π°Π½Ρ‚Ρ‹)
Information on the nature of radiation-associated mutations suggests that DNA-loss events (gene deletions) will tend to dominate this mutational component.
Π˜Π½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΡ ΠΎ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π΅ Π²Ρ‹Π·Π²Π°Π½Π½Ρ‹Ρ… Ρ€Π°Π΄ΠΈΠ°Ρ†ΠΈΠ΅ΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚, Ρ‡Ρ‚ΠΎ процСсс ΠΏΠΎΡ‚Π΅Ρ€ΠΈ Π”ΠΠš (исчСзновСниС Π³Π΅Π½ΠΎΠ²) Π±ΡƒΠ΄Π΅Ρ‚, скорСС всСго, Π΄ΠΎΠΌΠΈΠ½ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π² этой ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰Π΅ΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ.
Importantly, the key mutational events in cancer development are frequently dependent on the organ in which the irradiated cell is located and fall into two general categories -- small specific mutations in single genes and mutations involving loss of DNA (sometimes spanning more than one gene).
И Π²Π°ΠΆΠ½ΠΎ ΠΎΡ‚ΠΌΠ΅Ρ‚ΠΈΡ‚ΡŒ, Ρ‡Ρ‚ΠΎ основныС ΠΌΠΎΠΌΠ΅Π½Ρ‚Ρ‹ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΈ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ Ρ€Π°ΠΊΠ° часто зависят ΠΎΡ‚ ΠΎΡ€Π³Π°Π½Π°, Π² ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΌ находится облучСнная ΠΊΠ»Π΅Ρ‚ΠΊΠ°, ΠΈ ΠΎΠ½ΠΈ ΠΏΠΎΠ΄Ρ€Π°Π·Π΄Π΅Π»ΡΡŽΡ‚ΡΡ Π½Π° Π΄Π²Π΅ ΠΎΠ±Ρ‰ΠΈΠ΅ ΠΊΠ°Ρ‚Π΅Π³ΠΎΡ€ΠΈΠΈ - ΠΌΠ΅Π»ΠΊΠΈΠ΅ ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ ΠΎΡ‚Π΄Π΅Π»ΡŒΠ½Ρ‹Ρ… Π³Π΅Π½ΠΎΠ² ΠΈ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ приводят ΠΊ ΠΏΠΎΡ‚Π΅Ρ€Π΅ Π”ΠΠš (ΠΈΠ½ΠΎΠ³Π΄Π° это Π·Π°Ρ‚Ρ€Π°Π³ΠΈΠ²Π°Π΅Ρ‚ Π½Π΅ ΠΎΠ΄ΠΈΠ½ Π³Π΅Π½).
A small fraction of such mutations can contribute to cancer development.
Π”Π°ΠΆΠ΅ нСбольшая Ρ‡Π°ΡΡ‚ΡŒ Ρ‚Π°ΠΊΠΈΡ… ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ ΠΌΠΎΠΆΠ΅Ρ‚ привСсти ΠΊ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΡŽ Ρ€Π°ΠΊΠ°.
The test lies only in these mutations being made productive.
ΠŸΡ€ΠΎΠ²Π΅Ρ€ΠΊΡƒ проходят лишь Ρ‚Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ.
16. There has been progress in identifying resistance genes, in identifying mutations which lead to these resistance genes, and in knowing whether mutations for resistance impact replication and pathogenicity.
16. Π˜ΠΌΠ΅ΡŽΡ‚ΡΡ ΠΏΠΎΠ΄Π²ΠΈΠΆΠΊΠΈ Π² ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ Π³Π΅Π½ΠΎΠ² устойчивости, Π² ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ приводят ΠΊ появлСнию этих Π³Π΅Π½ΠΎΠ² устойчивости, ΠΈ Π² уяснСнии Ρ‚ΠΎΠ³ΠΎ, Π²Π»ΠΈΡΡŽΡ‚ Π»ΠΈ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, Π²Π΅Π΄ΡƒΡ‰ΠΈΠ΅ ΠΊ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΡŽ рСзистСнтности, Π½Π° Ρ€Π΅ΠΏΠ»ΠΈΠΊΠ°Ρ†ΠΈΡŽ ΠΈ ΠΏΠ°Ρ‚ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒ.
A forced mutation of this rich mosaic into uniformity would be destabilizing.
ΠΠ°ΡΠΈΠ»ΡŒΡΡ‚Π²Π΅Π½Π½Π°Ρ мутация этой Π±ΠΎΠ³Π°Ρ‚ΠΎΠΉ ΠΌΠΎΠ·Π°ΠΈΠΊΠΈ Π² Π΅Π΄ΠΈΠ½ΠΎΠΎΠ±Ρ€Π°Π·Π½ΡƒΡŽ Ρ„ΠΎΡ€ΠΌΡƒ ΠΌΠΎΠ³Π»Π° Π±Ρ‹ ΡΡ‚Π°Ρ‚ΡŒ Π΄Π΅ΡΡ‚Π°Π±ΠΈΠ»ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΌ Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ.
(a) Include new estimates of the spontaneous mutation rate in humans;
a) Π²ΠΊΠ»ΡŽΡ‡ΠΈΡ‚ΡŒ Π½ΠΎΠ²Ρ‹Π΅ ΠΎΡ†Π΅Π½ΠΊΠΈ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ, спонтанно Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΡ… Π² ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ΅ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°;
It's a mutation, it's a very groovy mutation.
Π­Ρ‚ΠΎ мутация. ΠžΡ‡Π΅Π½ΡŒ ΡΠΎΠ±Π»Π°Π·Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Π°Ρ мутация.
and biological mutations.
ΠΈ биологичСских ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ.
Begin nano-mutation.
Π—Π°ΠΏΡƒΡΠΊΠ°ΡŽ Π½Π°Π½ΠΎ-ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ!
The mutation's too strong.
ΠœΡƒΡ‚Π°Ρ†ΠΈΡ слишком сильна.
Adaptive mutated bacteria fissures
Π‘Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ΠΈ Π°Π΄Π°ΠΏΡ‚ΠΈΠ²Π½ΠΎΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ.
RAF1 mutation right there.
ΠœΡƒΡ‚Π°Ρ†ΠΈΡ Π³Π΅Π½Π° RAF1.
All its beautiful mutations.
Π­Ρ‚ΠΈ чудСсныС ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ.
about the virus mutation?
ΠΏΡ€ΠΎ ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ вируса?
Her mutation is unique.
Π•Π΅ мутация ΡƒΠ½ΠΈΠΊΠ°Π»ΡŒΠ½Π°.
To breed out the mutation.
Π§Ρ‚ΠΎΠ±Ρ‹ ΠΈΡΠΊΠ»ΡŽΡ‡ΠΈΡ‚ΡŒ ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ.
It had been discovered that phages could have mutations which would affect their ability to attack bacteria, and we were supposed to study those mutations.
К Ρ‚ΠΎΠΌΡƒ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ Π²Ρ‹ΡΡΠ½ΠΈΠ»ΠΎΡΡŒ, Ρ‡Ρ‚ΠΎ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ΠΈ ΠΌΠΎΠ³ΡƒΡ‚ ΠΏΡ€Π΅Ρ‚Π΅Ρ€ΠΏΠ΅Π²Π°Ρ‚ΡŒ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, ΠΏΠΎΠ²Ρ€Π΅ΠΆΠ΄Π°ΡŽΡ‰ΠΈΠ΅ ΠΈΡ… ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡ‚Π²ΠΎΠ²Π°Ρ‚ΡŒ Π½Π° Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ,Β β€” ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π»ΠΎΡΡŒ, Ρ‡Ρ‚ΠΎ ΠΌΡ‹ займСмся ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ΠΌ этих ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΉ.
The second mutation was either one in which an extra base was put back in, or two more were taken out.
ΠŸΡ€ΠΈ Π²Ρ‚ΠΎΡ€ΠΎΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ ΠΊΠΎΠ΄ Π»ΠΈΠ±ΠΎ восстанавливался, Π»ΠΈΠ±ΠΎ воссоздавался.
The most interesting feature, of course, is their eyesβ€”totally blue, no whites in them." "Mutation?" "No;
Но, бСзусловно, самая интСрСсная ΠΈΡ… Ρ‡Π΅Ρ€Ρ‚Π° – Π³Π»Π°Π·Π°. Π‘ΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½Π½ΠΎ синиС, Π±Π΅Π· ΠΊΠ°ΠΏΠ»ΠΈ Π±Π΅Π»ΠΈΠ·Π½Ρ‹. β€“Β ΠœΡƒΡ‚Π°Ρ†ΠΈΡ? – НСт.
There were also some phages that would have a second mutation which would reconstitute their ability to attack bacteria.
БущСствовали Π΅Ρ‰Π΅ ΠΈ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ΠΈ, ΠΏΠ΅Ρ€Π΅ΠΆΠΈΠ²Π°Π²ΡˆΠΈΠ΅ Π²Ρ‚ΠΎΡ€ΡƒΡŽ ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ, которая восстанавливала эту ΠΈΡ… ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ.
I gave a talk to the biology department about the double mutations which occurred so close together.
Π― ΠΏΡ€ΠΎΡ‡ΠΈΡ‚Π°Π» Π² биологичСском ΠΎΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠΈ Π΄ΠΎΠΊΠ»Π°Π΄ ΠΎ Π΄Π²ΠΎΠΉΠ½Ρ‹Ρ… мутациях, происходящих Π² тСсной близости ΠΎΠ΄Π½Π° ΠΎΡ‚ Π΄Ρ€ΡƒΠ³ΠΎΠΉ.
I told them my guess was that one mutation made a change in the protein, such as changing the pH of an amino acid, while the other mutation made the opposite change on a different amino acid in the same protein, so that it partially balanced the first imitationβ€”not perfectly, but enough to let the phage operate again.
Рассказал ΠΎ ΠΌΠΎΠ΅ΠΌ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ насчСт Ρ‚ΠΎΠ³ΠΎ, Ρ‡Ρ‚ΠΎ ΠΎΠ΄Π½Π° мутация ΠΏΡ€Π΅ΠΎΠ±Ρ€Π°Π·ΡƒΠ΅Ρ‚ Π±Π΅Π»ΠΎΠΊ, измСняя, скаТСм, рН аминокислоты, Π° другая ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡ‚ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠΏΠΎΠ»ΠΎΠΆΠ½ΠΎΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Ρ€ΡƒΠ³ΠΎΠΉ аминокислоты Ρ‚ΠΎΠ³ΠΎ ΠΆΠ΅ Π±Π΅Π»ΠΊΠ°, частично ΡƒΡ€Π°Π²Π½ΠΎΠ²Π΅ΡˆΠΈΠ²Π°Ρ ΠΏΠ΅Ρ€Π²ΡƒΡŽ ΠΌΡƒΡ‚Π°Ρ†ΠΈΡŽ,Β β€” Π½Π΅ ΠΏΠΎΠ»Π½ΠΎΡΡ‚ΡŒΡŽ, Π½ΠΎ Π² ΠΌΠ΅Ρ€Π΅, достаточной, Ρ‡Ρ‚ΠΎΠ±Ρ‹ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ смог снова Ρ€Π°Π±ΠΎΡ‚Π°Ρ‚ΡŒ, ΠΊΠ°ΠΊ ΠΏΡ€Π΅ΠΆΠ΄Π΅.
It was a slow job. It was sort of accidental: You had to wait around until von got a double mutation, which was very rare.
Π Π°Π±ΠΎΡ‚Π° Π±Ρ‹Π»Π° мСдлСнная ΠΈ построСнная Π½Π° своСго Ρ€ΠΎΠ΄Π° случайности: Π²Π°ΠΌ ΠΏΡ€ΠΈΡ…ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ Π΄ΠΎΠΆΠΈΠ΄Π°Ρ‚ΡŒΡΡ Π΄Π²ΠΎΠΉΠ½ΠΎΠΉ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ, Π° такая ΡΠ»ΡƒΡ‡Π°Π»Π°ΡΡŒ ΠΎΡ‡Π΅Π½ΡŒ Ρ€Π΅Π΄ΠΊΠΎ.
In other words, there were β€œback mutations, but they weren’t always perfect; sometimes the phage would recover only part of the ability it had lost.
Π˜Π½Ρ‹ΠΌΠΈ словами, Β«ΠΎΠ±Ρ€Π°Ρ‚Π½Ρ‹Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈΒ» сущСствовали, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΎΠ½ΠΈ Π½Π΅ всСгда Π±Ρ‹Π»ΠΈ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½Π½Ρ‹ΠΌΠΈ β€” ΠΏΠΎ Π²Ρ€Π΅ΠΌΠ΅Π½Π°ΠΌ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ восстанавливал лишь Ρ‡Π°ΡΡ‚ΡŒ ΡƒΡ‚Ρ€Π°Ρ‡Π΅Π½Π½ΠΎΠΉ ΠΈΠΌ способности.
Bob Edgar suggested that I do an experiment which would try to find out if the back mutations occurred in the same place on the DNA spiral.
Π‘ΠΎΠ± Π­Π΄Π³Π°Ρ€ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠΈΠ» ΠΌΠ½Π΅ провСсти экспСримСнты ΠΈ ΠΏΠΎΠΏΡ‹Ρ‚Π°Ρ‚ΡŒΡΡ Π²Ρ‹ΡΡΠ½ΠΈΡ‚ΡŒ, происходят Π»ΠΈ ΠΎΠ±Ρ€Π°Ρ‚Π½Ρ‹Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ Π² Ρ‚Π΅Ρ… ΠΆΠ΅ самых участках спирали Π”ΠΠš.
I kept trying to think of ways to make a phage mutate more often and how to detect mutations more quickly, but before I could come up with a good technique the summer was over, and I didn’t feel like continuing on that problem.
Π― всС пытался ΠΏΡ€ΠΈΠ΄ΡƒΠΌΠ°Ρ‚ΡŒ, ΠΊΠ°ΠΊ Π±Ρ‹ Π·Π°ΡΡ‚Π°Π²ΠΈΡ‚ΡŒ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΎΡ„Π°Π³ΠΈ ΠΌΡƒΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Ρ‡Π°Ρ‰Π΅, Π° сами ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠΈΠ²Π°Ρ‚ΡŒ быстрСС, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΡ€Π΅ΠΆΠ΄Π΅ Ρ‡Π΅ΠΌ я Π΄ΠΎ Ρ‡Π΅Π³ΠΎ-Π»ΠΈΠ±ΠΎ додумался, Π»Π΅Ρ‚ΠΎ Π·Π°ΠΊΠΎΠ½Ρ‡ΠΈΠ»ΠΎΡΡŒ, Π° ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠ°Ρ‚ΡŒ ΠΈ дальшС Π·Π°Π½ΠΈΠΌΠ°Ρ‚ΡŒΡΡ этой ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠΎΠΉ ΠΌΠ½Π΅ Π½Π΅ Ρ…ΠΎΡ‚Π΅Π»ΠΎΡΡŒ.
The rapid expansion of extrabudgetary resources has led to its mutation.
Быстрый рост объСма Π²Π½Π΅Π±ΡŽΠ΄ΠΆΠ΅Ρ‚Π½Ρ‹Ρ… рСсурсов ΠΏΡ€ΠΈΠ²Π΅Π» ΠΊ ΠΈΡ… измСнСнию.
48. Admittedly, terrorism in our day is undergoing all kinds of mutations.
48. НСсомнСнно, Π² соврСмСнном ΠΌΠΈΡ€Π΅ тСррористичСская Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΏΡ€Π΅Ρ‚Π΅Ρ€ΠΏΠ΅Π²Π°Π΅Ρ‚ всСвозмоТныС измСнСния 49/.
Public administration, public management and good governance: conceptual mutations and cumulative paradigm shifts
ГосударствСнно-административная Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ, государствСнный ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚ ΠΈ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ Π±Π»Π°Π³ΠΎΠ³ΠΎ управлСния: смСщСниС понятий ΠΈ ΠΎΠ±Ρ‰ΠΈΠ΅ ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ измСнСния
II. Public administration, public management and good governance: conceptual mutations and cumulative paradigm shifts
II. ГосударствСнно-административная Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ, государствСнный ΠΌΠ΅Π½Π΅Π΄ΠΆΠΌΠ΅Π½Ρ‚ ΠΈ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ Π±Π»Π°Π³ΠΎΠ³ΠΎ управлСния: смСщСниС понятий ΠΈ ΠΎΠ±Ρ‰ΠΈΠ΅ ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ измСнСния
Changes in the balance of power and the dynamism of international relations often mutate unforeseeably into chaotic scenes of tense contradiction and conflict.
ИзмСнСния Π² балансС сил, Π΄ΠΈΠ½Π°ΠΌΠΈΠ·ΠΌ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ Π·Π°Ρ‡Π°ΡΡ‚ΡƒΡŽ Ρ‚Ρ€Π°Π½ΡΡ„ΠΎΡ€ΠΌΠΈΡ€ΡƒΡŽΡ‚ΡΡ Π² Ρ…Π°ΠΎΡ‚ΠΈΡ‡Π½ΡƒΡŽ, Ρ‚Ρ€ΡƒΠ΄Π½ΠΎΠΏΡ€Π΅Π΄ΡΠΊΠ°Π·ΡƒΠ΅ΠΌΡƒΡŽ ΠΊΠ°Ρ€Ρ‚ΠΈΠ½Ρƒ напряТСнных ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€Π΅Ρ‡ΠΈΠΉ ΠΈ ΠΊΠΎΠ½Ρ„Π»ΠΈΠΊΡ‚ΠΎΠ².
2000 Le droit tunisien du travail et les mutations internationales, in MΓ©langes Habib Ayadi, CPU, Tunis.
2000 Π³ΠΎΠ΄ "ВунисскоС ΠΏΡ€Π°Π²ΠΎ Π½Π° Ρ‚Ρ€ΡƒΠ΄ ΠΈ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Π΅ измСнСния", Melanges Habib AYADI, ΠΈΠ·Π΄Π°Π½ΠΈΠ΅ CPU , Вунис
The high numbers of diplomats in, particularly the positions of Ambassador and Consul, ensue from mutations that took place during the reporting period.
Рост числа ΠΆΠ΅Π½Ρ‰ΠΈΠ½ Π½Π° дипломатичСских долТностях, Π² частности Π½Π° долТностях послов ΠΈ консулов, обусловлСн измСнСниями, ΠΏΡ€ΠΎΠΈΠ·ΠΎΡˆΠ΅Π΄ΡˆΠΈΠΌΠΈ Π·Π° ΠΎΡ‚Ρ‡Π΅Ρ‚Π½Ρ‹ΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄.
The new Office should build up its capacities and receive more resources to be able to keep up with mutations of conflicts in that region.
НовоС ΠžΡ‚Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΡƒΠΊΡ€Π΅ΠΏΠΈΡ‚ΡŒ свой ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π» ΠΈ ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ большС рСсурсов, с Ρ‚Π΅ΠΌ Ρ‡Ρ‚ΠΎΠ±Ρ‹ ΠΈΠΌΠ΅Ρ‚ΡŒ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ Ρ€Π΅Π°Π³ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π½Π° измСнСния Π² Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΊΠΎΠ½Ρ„Π»ΠΈΠΊΡ‚Π°Ρ….
155. The national-level standoff between TFG and the Mogadishu-based opposition has now mutated to include a powerful militant fundamentalist element.
155. Π’ схСмС ΠΎΠ±Ρ‰Π΅Π½Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ противостояния ЀПП ΠΈ Π±Π°Π·ΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΉΡΡ Π² Могадишо ΠΎΠΏΠΏΠΎΠ·ΠΈΡ†ΠΈΠΈ ΠΏΡ€ΠΎΠΈΠ·ΠΎΡˆΠ»ΠΈ измСнСния: появился Π½ΠΎΠ²Ρ‹ΠΉ ΠΌΠΎΡ‰Π½Ρ‹ΠΉ элСмСнт -- Π²ΠΎΠΈΠ½ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ фундамСнталисты.
The incredible, unhoped-for mutation was both... beneficial and fatal to me.
Π― Π±Ρ‹Π» ΡƒΠ²Π»Π΅Ρ‡Ρ‘Π½ Ρ€Π°Π· ΠΈ навсСгда. НСоТиданноС ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅, Π±Π»Π°Π³ΠΎΡ‚Π²ΠΎΡ€Π½ΠΎΠ΅ ΠΈ Ρ„Π°Ρ‚Π°Π»ΡŒΠ½ΠΎΠ΅.
Dan has a heart condition known as HCM. It's a... genetic mutation.
Π£ Π”Π΅Π½Π° болСзнь сСрдца, извСстная ΠΊΠ°ΠΊ гипСртрофичСская кардиомиопатия Π­Ρ‚ΠΎ ...наслСдствСнноС ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅
Some kind of lifeform probably evolved or underwent some unexpected mutation... Wait a second... nothing can evolve that quick...
Π»ΠΈΠ±ΠΎ ΠΏΡ€Π΅Π²Ρ€Π°Ρ‚ΠΈΠ»ΠΎΡΡŒ Π²Π½Π΅Π·Π°ΠΏΠ½ΠΎ... Ρ‚Π°ΠΊΠΈΠ΅ измСнСния Ρ‚Π°ΠΊ Π»Π΅Π³ΠΊΠΎ Π½Π΅...
That's not exactly a mutation that would get you into Xavier's School for Gifted Youngsters, but go on.
Π­Ρ‚ΠΎ Π½Π΅ совсСм Ρ‚ΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΠΌΠΎΠ³Π»ΠΎ ΠΏΠΎΠΌΠΎΡ‡ΡŒ Ρ‚Π΅Π±Π΅ Π² школС КсавьС для ΠΎΠ΄Π°Ρ€Π΅Π½Π½ΠΎΠΉ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ, Π½ΠΎ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠΈΠΌ
Anther and microspore culture techniques, to obtain homozygous diploid mutants following irradiation, are frequently used in several mutation-breeding projects supported by the Agency.
Π’ рядС ΠΏΡ€ΠΎΠ΅ΠΊΡ‚ΠΎΠ² Π² области ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ развСдСния, ΠΏΠΎΠ΄Π΄Π΅Ρ€ΠΆΠΈΠ²Π°Π΅ΠΌΡ‹Ρ… АгСнтством, часто ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ ΠΏΡ‹Π»ΡŒΠ½ΠΈΠΊΠΎΠ²Ρ‹Ρ… ΠΈ микроспоровых ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€ для получСния Π³ΠΎΠΌΠΎΠ·ΠΈΠ³ΠΎΡ‚Π½Ρ‹Ρ… Π΄ΠΈΠΏΠ»ΠΎΠΈΠ΄Π½Ρ‹Ρ… ΠΌΡƒΡ‚Π°Π½Ρ‚ΠΎΠ² Π² процСссС Ρ€Π°Π΄ΠΈΠΎΠ°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ облучСния.
He saw the heart-rending, dead, depopulated city that had housed the plant workers, to which it will be hardly possible to return for centuries. In the 30-kilometre zone, he saw abandoned villages, mutated forests, millions of tonnes of radioactive mud.
Он Π²ΠΈΠ΄Π΅Π» морозящий Π΄ΡƒΡˆΡƒ, ΠΌΠ΅Ρ€Ρ‚Π²Ρ‹ΠΉ, Π±Π΅Π·Π»ΡŽΠ΄Π½Ρ‹ΠΉ Π³ΠΎΡ€ΠΎΠ΄ Π°Ρ‚ΠΎΠΌΡ‰ΠΈΠΊΠΎΠ², Π² ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ вряд Π»ΠΈ вСрнутся Π² блиТайшСС столСтиС люди, ΠΏΠΎΠΊΠΈΠ½ΡƒΡ‚Ρ‹Π΅ сСла, лСса-ΠΌΡƒΡ‚Π°Π½Ρ‚Ρ‹, ΠΌΠΈΠ»Π»ΠΈΠΎΠ½Ρ‹ Ρ‚ΠΎΠ½Π½ Ρ€Π°Π΄ΠΈΠΎΠ°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠΉ грязи Π² Ρ‚Ρ€ΠΈΠ΄Ρ†Π°Ρ‚ΠΈΠΊΠΈΠ»ΠΎΠΌΠ΅Ρ‚Ρ€ΠΎΠ²ΠΎΠΉ Π·ΠΎΠ½Π΅.
93. A number of small-berried varieties were added to the exhaustive list of small berried varieties: [Black Seedless,] Centennial Seedless, Crimson Seedless, Dawn Seedless, Eclipse Seedless, Muscat Seedless, Muska, Pirobella, Sharat Seedless (Kishmi Chorni), Thompson Seedless and Mutations, Sundance and Sunred Seedless.
93. Π’ ΠΈΡΡ‡Π΅Ρ€ΠΏΡ‹Π²Π°ΡŽΡ‰ΠΈΠΉ ΠΏΠ΅Ρ€Π΅Ρ‡Π΅Π½ΡŒ ΠΌΠ΅Π»ΠΊΠΎΠΏΠ»ΠΎΠ΄Π½Ρ‹Ρ… разновидностСй Π±Ρ‹Π»ΠΈ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Ρ‹: [Black Seedless,] Centennial Seedless, Crimson Seedless, Dawn Seedless, Eclipse Seedless, Muscat Seedless, Muska, Pirobella, Sharat Seedless (Kishmi Chorni), Thompson Seedless ΠΈ ΠΌΡƒΡ‚Π°Π½Ρ‚Ρ‹, Sundance ΠΈ Sunred Seedless.
(Daniel) They're all mutated.
Они всС ΠΌΡƒΡ‚Π°Π½Ρ‚Ρ‹.
Wastelands breed mutations
Π’ ΠΏΡƒΡΡ‚ΠΎΡˆΠ°Ρ… ΠΏΠΎΠ»Π½ΠΎ ΠΌΡƒΡ‚Π°Π½Ρ‚ΠΎΠ².
The lake is full of mutations....
ΠžΠ·Π΅Ρ€ΠΎ ΠΏΠΎΠ»Π½ΠΎ ΠΌΡƒΡ‚Π°Π½Ρ‚ΠΎΠ²....
How are all the mutations cool?
ΠŸΠΎΡ‡Π΅ΠΌΡƒ всС ΠΌΡƒΡ‚Π°Π½Ρ‚Ρ‹ ΠΊΠ»Π΅Π²Ρ‹Π΅?
Well, they called you mutations.
Ну, ΠΎΠ½ΠΈ Π½Π°Π·Π²Π°Π»ΠΈ нас ΠΌΡƒΡ‚Π°Π½Ρ‚Π°ΠΌΠΈ.
Take that, you mutated son of a bitch!
ΠŸΠΎΠ»ΡƒΡ‡Π°ΠΉ, Ρ‡Π΅Ρ€Ρ‚ΠΎΠ² ΠΌΡƒΡ‚Π°Π½Ρ‚!
The lake didn't mutate me.
Π‘Ρ‚Ρ€Π°Π½Π½ΠΎ... Π²ΠΎΠ΄Ρ‹ Π½Π΅ сдСлали мСня ΠΌΡƒΡ‚Π°Π½Ρ‚ΠΎΠΌ?
You're not mutation. You're evolution.
Π’Ρ‹ Π½Π΅ ΠΌΡƒΡ‚Π°Π½Ρ‚, Ρ‚Ρ‹ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ ΡΠ²ΠΎΠ»ΡŽΡ†ΠΈΠΈ.
The waters can't mutate us mutants!
Π’ΠΎΠ΄Ρ‹ Π½Π΅ заставят ΠΌΡƒΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ нас, ΠΌΡƒΡ‚Π°Π½Ρ‚Ρ‹!
Was trapped underneath a gigantic mutated squid,
Π‘Ρ‹Π»Π° Π·Π°ΠΏΠ΅Ρ€Ρ‚Π° ΠΏΠΎΠ΄ ΠΎΠ³Ρ€ΠΎΠΌΠ½Ρ‹ΠΌ ΠΊΠ°Π»ΡŒΠΌΠ°Ρ€ΠΎΠΌ-ΠΌΡƒΡ‚Π°Π½Ρ‚ΠΎΠΌ,
The world has undoubtedly changed since 1945, and remains in a state of permanent mutation, as the ongoing discussions on the international economic and financial architecture demonstrate.
По ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с 1945 Π³ΠΎΠ΄ΠΎΠΌ ΠΌΠΈΡ€, нСсомнСнно, измСнился, ΠΎΠ½ ΠΆΠΈΠ²Π΅Ρ‚ Π² состоянии постоянных ΠΏΠ΅Ρ€Π΅ΠΌΠ΅Π½, ΠΎ Ρ‡Π΅ΠΌ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠ°ΡŽΡ‰ΠΈΠ΅ΡΡ обсуТдСния ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠΉ экономичСской ΠΈ финансовой Π°Ρ€Ρ…ΠΈΡ‚Π΅ΠΊΡ‚ΡƒΡ€Ρ‹.
Furthermore, and in the face of the globalization and universalization that is engendering the arrogant triumphalism of the powerful, the international community must rise above the disparities among its members and find adequate ways of overcoming the negative impact on a fragile international balance of the mutations that are currently taking place.
ΠšΡ€ΠΎΠΌΠ΅ Ρ‚ΠΎΠ³ΠΎ, ΡΡ‚ΠΎΠ»ΠΊΠ½ΡƒΠ²ΡˆΠΈΡΡŒ с Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ ΠΈ унивСрсализациСй, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΏΠΎΡ€ΠΎΠΆΠ΄Π°ΡŽΡ‚ ΡΠ°ΠΌΠΎΠ½Π°Π΄Π΅ΡΠ½Π½ΠΎΡΡ‚ΡŒ Ρƒ ΡΠΈΠ»ΡŒΠ½Ρ‹Ρ… ΠΌΠΈΡ€Π° сСго, ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠ΅ сообщСство Π΄ΠΎΠ»ΠΆΠ½ΠΎ Π²ΡΡ‚Π°Ρ‚ΡŒ Π²Ρ‹ΡˆΠ΅ разногласий ΠΌΠ΅ΠΆΠ΄Ρƒ Π΅Π³ΠΎ государствами-Ρ‡Π»Π΅Π½Π°ΠΌΠΈ ΠΈ Π½Π°ΠΉΡ‚ΠΈ Π°Π΄Π΅ΠΊΠ²Π°Ρ‚Π½Ρ‹Π΅ ΠΏΡƒΡ‚ΠΈ прСодолСния Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ воздСйствия, ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ ΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ происходящиС Π² настоящСС врСмя ΠΏΠ΅Ρ€Π΅ΠΌΠ΅Π½Ρ‹ Π½Π° Π½Π΅ΡΡ‚Π°Π±ΠΈΠ»ΡŒΠ½ΠΎΠ΅ ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½ΠΎΠ΅ равновСсиС.
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